Joint pain is caused by various factors including muscle inflammation due to strenuous exercise and fatigue, but the decrease of cartilage that serves as a cushion in the joints is also one of the causes. Chondroitin sulfate is one of the components of cartilage that serves as a cushion in the joints. It has the role of giving the cartilage resilience and water retention to relieve the impact on the joints. The amount of chondroitin sulfate in the body decreases with age, reducing the cushioning function of cartilage and developing as joint pain.

Lower back pain is caused by a variety of factors, including poor posture, muscle weakness, excessive exercise, coldness, and poor circulation. However, another cause is aging (reduced function) of the intervertebral discs that serve as a cushion in the lumbar spine.
The intervertebral discs, which are highly elastic and rich in chondroitin sulfate, serve as a cushion against various types of pressure on the lower back.

Even if there is no pain in the shoulder, if you experience discomfort such as difficulty raising or turning the arms, there may be joint issues.
As the function of the scapula declines with age, the bones collide with each other, leading to inflammation of the “joint capsule,” the membrane covering the shoulder joint.

Pain caused by stimulation of the peripheral nerves due to various causes is called neuralgia. It is characterized by the sudden and repeated onset of sharp, intense, lightning pain. Nerves are protected by the myelin sheath. This is similar to the mechanism where electrical wires are covered in rubber to prevent electrical shock. Pain of neuralgia occurs when the myelin sheath that serves as a cover is damaged and the nerve is stimulated.

Hearing loss has various causes, including continued exposure to loud sounds, inflammation (middle ear, etc.), psychological causes, and aging. Hearing loss can be broadly divided into "conductive hearing loss," where the functions of the conductive system in the external ear and middle ear (transmission of sound by the tympanic membrane and auditory ossicles) are impaired, and "sensorineural hearing loss," where the functions of the internal/cochlear nerves and the central auditory pathway are impaired. The cochlea of the inner ear contains numerous hair cells that convert the sound vibrations into electrical signals. The Hair cells play an essential role in hearing.

There are various causes of physical fatigue, but one of the causes is the loss of chondroitin with age. Chondroitin in the connective tissue that connects cells involved in the transport of oxygen and nutrients to cells throughout the body.